Prioritizing genes for systematic variant effect mapping

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prioritizing Seafloor Mapping for Washington’s Pacific Coast

Remote sensing systems are critical tools used for characterizing the geological and ecological composition of the seafloor. However, creating comprehensive and detailed maps of ocean and coastal environments has been hindered by the high cost of operating ship- and aircraft-based sensors. While a number of groups (e.g., academic research, government resource management, and private sector) are...

متن کامل

Prioritizing Disease Genes by Bi-Random Walk

Random walk methods have been successfully applied to prioritizing disease causal genes. In this paper, we propose a bi-random walk algorithm (BiRW) based on a regularization framework for graph matching to globally prioritize disease genes for all phenotypes simultaneously. While previous methods perform random walk either on the proteinprotein interaction network or the complete phenome-genom...

متن کامل

Prioritizing Disease Genes and Understanding Disease Pathways

Genetic factors play a major role in the etiology of many human diseases. Genome-wide experimental methods produce an increasing number of genes associated with such diseases. This chapter introduces data sources, bioinformatics tools, and computational methods for prioritizing disease candidate genes and identifying disease pathways. The main strategy is to examine the similarity among the can...

متن کامل

Exploiting Negative Sample Selection for Prioritizing Candidate Disease Genes

A major challenge in bio-medicine is finding the genetic causes of human diseases, and researchers are often faced with a large number of candidate genes. Gene prioritization methods provide a valuable support in guiding researchers to detect reliable candidate causative-genes for a disease under study. Indeed, such methods rank genes according to their association with a disease of interest. A...

متن کامل

Tissue-Specific Functional Networks for Prioritizing Phenotype and Disease Genes

Integrated analyses of functional genomics data have enormous potential for identifying phenotype-associated genes. Tissue-specificity is an important aspect of many genetic diseases, reflecting the potentially different roles of proteins and pathways in diverse cell lineages. Accounting for tissue specificity in global integration of functional genomics data is challenging, as "functionality" ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Bioinformatics

سال: 2020

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btaa1008